Aminoplasmal Hepa 10% Dosage/Direction for Use

Depending on individual requirements.
Normal Dose: 7-10 mL/kg body weight/day, corresponding to 0.7-1 g of amino acids/kg body weight/day.
Maximum Dose: 15 mL/kg body weight/day, corresponding to 1.5 g of amino acids/kg body weight/day.
Flow Rate: Treatment of Hepatic Coma: In hepatic encephalopathy, it is recommended to start the infusion of Aminoplasmal Hepa-10% at an increased rate, until onset of the effect, eg for a patient weighing 70 kg:
1st-2nd hr: 150 mL/hr (2 mL/kg body weight/hr), corresponding to approximately 50 drops/min; 3rd-4th hr: 75 mL/hr (1 mL/kg body weight/hr), corresponding to approximately 25 drops/min; from 5th hr: 45 mL/hr (0.6 mL/kg body weight/hr), corresponding to approximately 15 drops/min.
Maintenance Requirements/Parenteral Nutrition: 45-75 mL/hr, corresponding to 15-25 drops/min (0.6-1 mL/kg body weight/hr).
Duration of Use: Aminoplasmal Hepa-10% may be administered as long as there is a risk of manifestation of hepatic encephalopathy.
Administration: IV infusion into the vena cava.